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Liquid chromatography has gained a status of utterly the most popular separation technique in the world. Any success in modern chemistry is hardly conceivable without the support of dozens of liquid chromatographs found in any larger laboratory. Based on a principle of chemical compounds being separated according to their different affinities to a mobile and a stationary phase, liquid chromatography is robust and easily operable. Simple enough for daily use but yet presenting new and new challenges to scientists who are still coming up with innovative separation modes and/or applications.
Starting from small inorganic ions, electrophoresis has developed into a versatile separation tool that is nowadays applied to pharmaceuticals as well as large biomolecules or even nanoparticles or living cells. It is based on the universal principle of charged species gaining different velocities under an influence of an electric field. While not yet as much popular as chromatography, electrophoresis benefits from being completely described mathematically. Thus novel electrophoretical strategies can be rationally designed often by means of a computer simulation.
Method development & phys-chem measurements
Carefully planned experiments serve us for not only supporting the wide community of analysts with newly developed methods but also for introducing original experimental setups and separation strategies. Last but not least, getting necessary input parameters for our theoretical models and experimental verification of these stays at the heart of our research strategy.
Software development & Mathematical modelling
Located at the department of Physical and macromolecular chemistry, we not merely utilize the two separation techniques but we are continuously making a journey into the tiniest details of their principles. This involves – among others – solving various mathematical problems from chemical equilibria to flux continuity equations. Finally, we build our gained knowledge into several software tools that come in handy to a wide community of separation scientists.